An increasing prevalence of hospital acquired infections and foodborne illnesses caused by pathogenic and multidrug resistant bacteria has stimulated a pressing need for benchtop computational methods to rapidly and accurately classify bacteria from genomic sequence data, and based on that, to trace the source of infection.
BacWGSTdb aims to provide a one-stop solution to epidemiological outbreak analysis and pioneer the movement of whole genome sequencing (WGS) from proof-of-concept studies to routine use in the clinical microbiology laboratory. Bench scientists can also use this database as a convenient tool for phylogenetic analysis of bacterial genomes.
Ye Feng, Shengmei Zou, Hangfei Chen, Yunsong Yu, Zhi Ruan. BacWGSTdb 2.0: a one-stop repository for bacterial whole-genome sequence typing and source tracking, Nucleic Acids Research. 2020. doi: 10.1093/nar/gkaa821.
Zhi Ruan, Ye Feng. BacWGSTdb, a database for genotyping and source tracking bacterial pathogens, Nucleic Acids Research. 2016; 44(D1): D682-D687.
Zhi Ruan, Yunsong Yu, Ye Feng. The global dissemination of bacterial infections necessitates the study of reverse genomic epidemiology, Briefings in Bioinformatics. 2020; 21(2): 741-750.